Enhancing clinical research quality and safety through specialized nursing
Just wondering if anyone weighs their IV bag to help determine total volume when it's unclear due to the standard over/underfill of the standard IV solution bags? Any insight would be appreciated!
if you work with a pharmacy or research pharmacy I would ask them this question. I know when I worked at an academic center the pharmacy would weigh IV bags for final volume especially where overfill was concerned but you have to follow a specific procedure and I would highly recommend a pharmacy do this not nurses at the bedside. Here is some guidance I found https://www.fda.gov/media/155066/download the fda guidance references USP 697 and 1151, but I haven’t found anything that is really helpful in that regard there would definitely need to be some measuring and validity testing to confirm the volume. You’d have to weigh each bag against an expected known weight for the final dose for confirmation. Honestly, this should be done by the sponsor and they should tell you what the weight should be after reconstitution, if they are asking sites to perform this measurement. What I’ve typically seen is sites need to ensure that the drug in the IV tubing is fully infused and that usually means additional orders to add 50 mls to the IV bag and infuse the final volume to ensure what was in the tubing was administered. Hope that helps! But again highly recommend you talk to a pharmacist or the sponsor as this is out of the scope of a research nurse in my opinion. Thanks!
International Association of Clinical Research Nurses
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